Research
Mixed
Hyperuricemia is an independent risk factor for developing hypertension and diabetes, with every 1 mg/dL increase in serum uric acid increasing the risk of hypertension by 19% and diabetes by 27%.
High uric acid is not just about gout; it independently raises your risk of high blood pressure and diabetes. If your uric acid is high, addressing it (often through diet, specifically reducing fructose and purines) may help prevent these conditions.
GoodSupportsHIGH confidence
Every 1-mg/dL increase in serum uric acid was associated with a 19% increased risk for developing hypertension (95% CI: 1.11-1.27) and a 27% increased risk for developing DM (95% CI: 1.10-1.45) in adjusted analyses.
Why this rating
Large cohort, longitudinal, adjusted for confounders, clear dose-response relationship.
Source
“Metabolically Healthy” Obesity and Hyperuricemia Increase Risk for Hypertension and Diabetes: 5‐year Japanese Cohort Study
Masanari Kuwabara et al. · Obesity · 2017
DOI 10.1002/oby.22000
cohort · n=9721Cited 90×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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