Energy balance
Sibutramine (10-30 mg/day) produces significant weight loss in overweight women primarily through appetite suppression (anorectic effect) rather than by increasing Resting Metabolic Rate (RMR).
Sibutramine is an effective weight-loss drug for overweight women, but it works by reducing appetite, not by speeding up your metabolism. Expect to lose about 7-8% of body weight over 8 weeks when combined with a controlled diet (1200 kcal/day). Do not rely on it to increase your resting energy expenditure.
In summary, while sibutramine was shown to be an effective weight-loss agent over 8 weeks, we found no evidence that it increased RMR.
Why this rating
Randomized, double-blind, placebo-controlled clinical trial with adequate sample size (n=44) and rigorous metabolic measurement.
Source
Effects of Sibutramine on Resting Metabolic Rate and Weight Loss in Overweight Women
Helen Seagle et al. · Obesity Research · 1998
DOI 10.1002/j.1550-8528.1998.tb00324.x
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