Mixed
The vast majority of established obesity-predisposing genetic loci do not significantly influence weight loss or weight regain outcomes in response to lifestyle interventions.
Do not rely on commercial genetic tests for common obesity genes (like FTO) to predict whether a diet or exercise program will work for you. This research indicates that for most genetic variants associated with obesity, there is no significant difference in how well people respond to lifestyle interventions. Focus on proven lifestyle strategies (caloric deficit, physical activity) rather than genetic testing for prediction.
Most obesity-predisposing gene variants were not associated with weight loss or regain within the DPP and Look AHEAD trials, directly or via interactions with lifestyle.
Why this rating
Based on two large, multi-center RCTs with rigorous statistical correction for multiple testing (Bonferroni threshold), providing high-confidence evidence of non-effect for most loci.
Source
Genetic Predisposition to Weight Loss and Regain With Lifestyle Intervention: Analyses From the Diabetes Prevention Program and the Look AHEAD Randomized Controlled Trials
George D. Papandonatos et al. · Diabetes · 2015
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