Mixed
Excessive training volume (e.g., >20-30 sets per session) may impair recovery and lead to negative adaptations or a plateau in hypertrophy, suggesting an upper threshold exists.
While more sets generally lead to more muscle, there is an upper limit. If you are doing very high volumes (e.g., 20+ sets per session), you may be impairing recovery. Consider distributing volume across multiple sessions or reducing volume to a manageable level (e.g., 10-20 sets per week) to optimize growth. Periodize your volume to avoid overtraining.
Wernbom et al. (33) suggested that a plateau of hypertrophic adaptations might occur after a certain point of volume, and moreover, the authors hypothesized the possibility of a decline in these adaptations when increasing training volume beyond that point... increases in trunk and arm lean body mass favored the lower-volume, 21-set group [compared to 31 sets].
Why this rating
Based on a single study comparing 21 vs 31 sets and a hypothesis from another review; limited empirical evidence for the upper threshold.
Source
Evidence-Based Guidelines for Resistance Training Volume to Maximize Muscle Hypertrophy
Brad J. Schöenfeld et al. · Strength and conditioning journal · 2017
DOI 10.1519/ssc.0000000000000363
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