Energy balance
Sustained moderate caloric restriction (average 11.9% reduction over 24 months) improves aging-related biomarkers and metabolic health without causing adverse psychological or behavioral outcomes in healthy, non-obese adults.
To improve aging biomarkers and metabolic health, aim for a moderate, sustained reduction in calorie intake (around 10-12%) over a long period (e.g., 2 years). This should be done with professional guidance, using behavioral strategies to maintain adherence, and ensuring you take a multivitamin and calcium supplement to prevent deficiencies. This approach is safe and effective even for non-obese individuals.
CALERIE 2 showed that moderate CR, 11.9% on average, induced improvements in aging-related biomarkers without adversely affecting psychological or behavioral outcomes.
Why this rating
Randomized controlled trial, large sample size (n=218), long duration (24 months), objective measures (DLW).
Source
Effects of caloric restriction on human physiological, psychological, and behavioral outcomes: highlights from CALERIE phase 2
James L. Dorling et al. · Nutrition Reviews · 2020
DOI 10.1093/nutrit/nuaa085
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