Research
Mixed
Intensive lifestyle intervention (ILI) does not significantly reduce the risk of major cardiovascular events (mortality, myocardial infarction, stroke) in adults with overweight/obesity and type 2 diabetes compared to standard diabetes support and education.
Even if lifestyle changes do not significantly lower your risk of heart attacks or death from cardiovascular causes, they still provide major benefits for your diabetes control, kidney health, and daily quality of life. The effort is still worthwhile for these other critical health improvements.
StrongRefutesHIGH confidence
The study was stopped for futility after a median of almost 10 years of intervention, as it was apparent that assignment to ILI was associated with a nonsignificant hazard ratio (HR) = 0.95 (95% CI: 0.83- 1.09) relative to DSE
Why this rating
Large, long-term RCT with clear primary endpoint analysis.
Source
Does Lifestyle Intervention Improve Health of Adults with Overweight/Obesity and Type 2 Diabetes? Findings from the Look AHEAD Randomized Trial
Rena R. Wing · Obesity · 2021
narrative_review · n=5145Cited 78×
Read the paper This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →