Mixed
In patients with type 2 diabetes mellitus, higher body weight variability (fluctuation) is associated with a significantly increased risk of cardiovascular events and mortality, independent of mean body weight and traditional risk factors.
If you have type 2 diabetes, avoiding large swings in your body weight is just as important for your heart health as maintaining a healthy average weight. Try to maintain consistent lifestyle habits rather than cycling through intense diets and regain, as this variability is linked to higher risks of heart attacks and stroke.
Among subjects with type 2 diabetes mellitus, fluctuation in body weight was associated with higher mortality and a higher rate of cardiovascular events, independent of traditional cardiovascular risk factors, mean body weight, and weight change.
Why this rating
Large sample size (n=6408), pooled from 3 randomized clinical trials, with rigorous adjustment for confounders; however, it is an observational analysis of trial data, not a randomized intervention on weight variability itself.
Source
Body Weight Variability and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus
Sripal Bangalore et al. · Circulation Cardiovascular Quality and Outcomes · 2018
DOI 10.1161/circoutcomes.118.004724
Related findings · Mixed
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