Hormonal
Adipocyte ATP-citrate lyase (ACLY) is essential for handling dietary carbohydrates and maintaining metabolic homeostasis in females, as its deficiency leads to lipodystrophy-like phenotypes, hepatic steatosis, and insulin resistance when consuming high-carbohydrate diets.
For women, high-carbohydrate diets may pose a higher metabolic risk if adipose tissue function is compromised, potentially leading to fat storage in the liver and insulin resistance. Men may tolerate similar carbohydrate loads better. This suggests that women might benefit from monitoring carbohydrate quality and quantity more closely, especially if they have underlying metabolic vulnerabilities.
When fed a high-sucrose diet, AclyFAT-/- females exhibit a lipodystrophy-like phenotype, with minimal fat accumulation, insulin resistance, and hepatic lipid accumulation, whereas AclyFAT-/- males have only mild metabolic phenotypes.
Why this rating
Strong experimental evidence using conditional knockout mice, RNA-seq, metabolite analysis, and in vivo feeding studies, though results are specific to mice.
Source
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
Sully Fernandez et al. · Cell Reports · 2019
DOI 10.1016/j.celrep.2019.04.112
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