Research
Hormonal
Adipocyte ACLY facilitates the activation of the transcription factor ChREBP, which is necessary for glucose uptake and de novo lipogenesis in adipose tissue.
This mechanism highlights why healthy fat storage is important for metabolic health. If the enzymes that help fat cells store energy properly are disrupted, sugar may end up in the liver instead, causing harm.
StrongSupportsVERY_HIGH confidence
ACLY is crucial for nutrient-dependent carbohydrate response element-binding protein (ChREBP) activation in adipocytes and plays a key role... in the storage of newly synthesized fatty acids in adipose tissue.
Why this rating
Direct molecular evidence via RNA-seq, metabolite analysis, and gene expression studies in cell culture and mice.
Source
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females
Sully Fernandez et al. · Cell Reports · 2019
DOI 10.1016/j.celrep.2019.04.112
mechanism_onlyCited 75×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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