Hormonal
Brainstem cholecystokinin-expressing (CCKAP/NTS) neurons are necessary for GLP-1 receptor agonists to induce conditioned taste avoidance (nausea/aversive effects).
The nausea and aversion caused by GLP-1 medications are mediated by specific brainstem neurons (CCKAP/NTS). Blocking these neurons prevents the aversive response, confirming that nausea is a central brain effect, not just a stomach issue. This knowledge helps in managing expectations and potentially developing strategies to reduce nausea.
We further show that... cholecystokinin-expressing neurons in the caudal brainstem are required for... the induction of GLP-1RA-induced conditioned taste avoidance.
Why this rating
Strong mechanistic evidence using loss-of-function models showing abolition of CTA.
Source
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
Alessia Costa et al. · Molecular Metabolism · 2021
DOI 10.1016/j.molmet.2021.101407
More from this paper
- Brainstem cholecystokinin-expressing (CCKAP/NTS) neurons are required for the appetite-suppressing and body-weight-lowering effects of GLP-1 receptor agonists.Good
- GIP receptor activation reduces the recruitment of CCKAP/NTS neurons and selectively reduces conditioned taste avoidance without abolishing weight loss.Good
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