Hormonal
Statin therapy is safe and effective for cardiovascular risk reduction in patients with MASLD and MASH, and elevated transaminases should not prevent prescription.
If you have fatty liver disease (MASLD/MASH), do not avoid statins due to fear of liver damage. Statins are safe, effective for heart health, and may even improve liver markers. Consult your doctor for appropriate intensity based on your overall cardiovascular risk.
Statin therapy represents an inexpensive, safe and effective therapy across the spectrum of non-alcohol related steatotic liver diseases without major safety concerns.
Why this rating
Supported by large meta-analyses and observational studies, though RCTs on liver histology are lacking.
Source
Cardiovascular Risk Reduction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis
J Bernhard et al. · Current Cardiology Reports · 2025
DOI 10.1007/s11886-024-02185-5
More from this paper
- Lifestyle modification, specifically weight loss of >5-10% and regular physical activity, is a cornerstone for improving liver fat and cardiovascular health in MASLD.Good
- GLP-1 receptor agonists (e.g., semaglutide, tirzepatide) show promising results for MASH resolution and weight loss, though phase 3 histological data is still emerging.Moderate
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