Research
Energy balance
Lifestyle modification, specifically weight loss of >5-10% and regular physical activity, is a cornerstone for improving liver fat and cardiovascular health in MASLD.
Aim for at least 5% weight loss and 150 minutes of exercise per week. This reduces liver fat. Losing 7-10% or more can further reduce inflammation and fibrosis. This is the foundation of MASLD treatment.
GoodSupportsHIGH confidence
Prospective data indicates positive effects on liver fat in patients with > 5% weight loss, with patients > 7–10% showing an additional reduction in inflammatory markers and fibrosis
Why this rating
Supported by large meta-analyses and guidelines.
Source
Cardiovascular Risk Reduction in Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Dysfunction-Associated Steatohepatitis
J Bernhard et al. · Current Cardiology Reports · 2025
DOI 10.1007/s11886-024-02185-5
narrative_reviewCited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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