Macro partitioning
Supplementation with plant sterols or plant stanols significantly reduces total cholesterol and LDL cholesterol in individuals with familial hypercholesterolemia.
If you have Familial Hypercholesterolemia, adding 2-3 grams of plant sterols or stanols daily to a standard cholesterol-lowering diet can significantly lower your total and LDL cholesterol. These are often found in fortified spreads or yogurts. This is an effective dietary adjunct, but it does not replace the need for medical management if prescribed.
In comparison with cholesterol-lowering diet, the additional consumption of plant stanols decreased total cholesterol (MD: −0.62 mmol/L, 95% CI: −1.13 to −0.11, p = 0.02) and low-density lipoprotein cholesterol (MD: −0.58 mmol/L, 95% CI: −1.08 to −0.09, p = 0.02). The same was by plant sterols (MD: −0.46 mmol/L, 95% CI: −0.76 to −0.17, p < 0.01 for cholesterol and MD: −0.45 mmol/L, 95% CI: −0.74 to −0.16, p < 0.01 for low-density lipoprotein cholesterol).
Why this rating
Meta-analysis of 17 RCTs with low/unclear bias risk, though no hard clinical endpoints (CVD incidence/mortality) were measured.
Source
Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis
Fotios Barkas et al. · Nutrients · 2020
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