Research
Macro partitioning
Soy protein intake does not significantly impact total cholesterol, LDL cholesterol, or triglycerides in individuals with familial hypercholesterolemia.
Increasing soy protein intake is not an effective strategy for lowering cholesterol in patients with Familial Hypercholesterolemia. The evidence shows no significant benefit for LDL or triglycerides compared to standard diets.
ModerateRefutesMEDIUM confidence
the dietary interventions increasing soy intake had no impact on study participants’ TC (MD: −0.19 mmol/L, 95% CI: −0.78 to 0.41), TG (MD: −0.14 mmol/L, 95% CI: −0.30 to 0.02), HDL-C (MD: 0.08 mmol/L, 95% CI: −0.06 to 0.22L), LDL-C (MD: −0.41 mmol/L, 95% CI: −0.99 to 0.18)...
Why this rating
Meta-analysis of 3 RCTs, but limited number of studies and mixed results on specific sub-markers.
Source
Diet and Cardiovascular Disease Risk Among Individuals with Familial Hypercholesterolemia: Systematic Review and Meta-Analysis
Fotios Barkas et al. · Nutrients · 2020
DOI 10.3390/nu12082436
Meta-analysis · 17 studiesCited 57×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Supplementation with plant sterols or plant stanols significantly reduces total cholesterol and LDL cholesterol in individuals with familial hypercholesterolemia.Good
- Supplementation with omega-3 fatty acids significantly reduces triglycerides in individuals with familial hypercholesterolemia, but has no significant impact on total or LDL cholesterol.Good
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