Research
Micronutrients & recovery
Mitochondria-targeted antioxidants (e.g., MitoQ, SkQ1) and polyphenols (e.g., Resveratrol) can extend lifespan and improve health in animal models by reducing ROS damage and mimicking caloric restriction effects, but human clinical efficacy is unproven and dosage is critical.
While mitochondria-targeted antioxidants and polyphenols show promise in animals, human evidence is mixed. Do not rely on supplements to replace exercise or healthy eating. If considering supplements like Resveratrol or MitoQ, be aware of poor bioavailability and lack of proven lifespan benefits in humans. Focus on whole-food sources of polyphenols.
ModerateQualifiesMEDIUM confidence
Polyphenols, such as resveratrol (RSV) or green tea polyphenols, were shown to extend lifespan in Saccharomyces cerevisiae, C. elegans, D. melanogaster, fish, and mice.
Why this rating
Strong animal data, but mixed or negative human clinical trial results.
Source
Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction
Corina T. Madreiter‐Sokolowski et al. · Genes · 2018
DOI 10.3390/genes9030165
narrative_reviewCited 57×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Mitochondrial dysfunction, characterized by ROS overproduction, Ca2+ overload, and structural changes, is a primary driver of cellular senescence and age-related diseases.Strong
- Caloric restriction (CR) and exercise extend lifespan and delay age-related diseases by targeting mitochondrial function, specifically through enhanced ATP production, improved Ca2+ homeostasis, and activation of AMPK/SIRT1 pathways.Good
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