Research

Micronutrients & recovery

Mitochondria-targeted antioxidants (e.g., MitoQ, SkQ1) and polyphenols (e.g., Resveratrol) can extend lifespan and improve health in animal models by reducing ROS damage and mimicking caloric restriction effects, but human clinical efficacy is unproven and dosage is critical.

While mitochondria-targeted antioxidants and polyphenols show promise in animals, human evidence is mixed. Do not rely on supplements to replace exercise or healthy eating. If considering supplements like Resveratrol or MitoQ, be aware of poor bioavailability and lack of proven lifespan benefits in humans. Focus on whole-food sources of polyphenols.

ModerateQualifiesMEDIUM confidence
Polyphenols, such as resveratrol (RSV) or green tea polyphenols, were shown to extend lifespan in Saccharomyces cerevisiae, C. elegans, D. melanogaster, fish, and mice.
Corina T. Madreiter‐Sokolowski et al. · Genes · 2018

Why this rating

Strong animal data, but mixed or negative human clinical trial results.

Source

Targeting Mitochondria to Counteract Age-Related Cellular Dysfunction

Corina T. Madreiter‐Sokolowski et al. · Genes · 2018

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