Energy balance
SANA (a nitroalkene derivative of salicylate) promotes weight loss and improves glucose management in humans through creatine-dependent thermogenesis, independent of UCP1 and AMPK.
SANA is an experimental drug that appears to trigger weight loss by increasing energy expenditure through creatine-dependent thermogenesis, rather than by suppressing appetite or increasing physical activity. In early human trials, doses of 200-400mg daily led to weight loss and improved glucose control within two weeks with a good safety profile. It works independently of the traditional UCP1 pathway, offering a potential alternative for those who do not respond to other mechanisms. Consult a physician for clinical trials or future availability.
SANA shows good safety and tolerability, and demonstrates beneficial effects on body weight and glucose management within 2 weeks of treatment. Overall, SANA appears to be a first-in-class activator of creatine-dependent energy expenditure and thermogenesis...
Why this rating
Evidence includes robust preclinical data (mice) and early-phase human trials (Phase 1A/B), but lacks large-scale long-term efficacy data.
Source
A nitroalkene derivative of salicylate, SANA, induces creatine-dependent thermogenesis and promotes weight loss
Karina Cal et al. · Nature Metabolism · 2025
DOI 10.1038/s42255-025-01311-z
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