Mixed
Resistance training increases the integrated rate of myofibrillar protein synthesis (MyoPS) and the synthesis rates of individual skeletal muscle proteins in older men during energy restriction, regardless of whether dietary protein is distributed evenly or skewed.
If you are an older adult trying to lose weight, focus on resistance training. The timing of your protein intake (whether you spread it out or eat it all at once) does not significantly impact your muscle protein synthesis rates as long as you are training. Prioritize the training stimulus over complex nutritional timing.
Bulk MyoPS was not affected by protein distribution during ER or ER+RT... but was ~26% higher during ER+RT than ER... The synthetic rates of 175 of 190 contractile, cytosolic and mitochondrial skeletal muscle proteins... were higher during ER+RT than ER.
Why this rating
Randomized controlled trial with objective isotopic measurements, though small sample size (n=20).
Source
Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction
C. H. Murphy et al. · The Journal of Physiology · 2018
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