Mixed
Among overweight and obese adults, there is no statistically significant interaction between insulin resistance status and weight loss outcomes when comparing low-fat and low-carbohydrate diets, provided both diets emphasize high nutritional quality and macronutrient differentiation.
If you are overweight or obese, focusing on high-quality foods (minimally processed, nutrient-dense) and reducing either fat or carbohydrates to a low level can lead to substantial weight loss. Your insulin resistance status does not appear to determine which of these two approaches works better for you. Choose the diet you can adhere to long-term, ensuring it is nutritionally dense.
No significant main effects were detected for weight loss by diet group or IR status; there was no significant diet × IR interaction.
Why this rating
Randomized pilot trial with adequate adherence but small sample size (n=61) and short duration (6 months), limiting statistical power to detect interactions.
Source
Weight loss on low‐fat vs. low‐carbohydrate diets by insulin resistance status among overweight adults and adults with obesity: A randomized pilot trial
Christopher D. Gardner et al. · Obesity · 2015
DOI 10.1002/oby.21331
Related findings · Mixed
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