Hormonal
High baseline insulin response (insulin-30) after weight loss predicts greater fat mass retention and lower resting energy expenditure (REE) during maintenance, identifying a phenotype at risk for weight regain.
If you have struggled to keep weight off despite losing it, your body may be secreting too much insulin in response to carbs, which stores fat and slows your metabolism. This is a specific biological phenotype, not a failure of willpower. The key lever is diet composition: starting your maintenance phase with a low-carbohydrate diet can 'reset' your insulin response and protect against this metabolic slowdown.
Insulin-30, but not maximal insulin secretion, hepatic IS, or HOMA, predicted changes in fat mass... Insulin-30... predicted change in REE during weight loss maintenance, independent of changes in body composition.
Why this rating
Randomized crossover trial with rigorous metabolic ward conditions, though small sample size (N=21).
Source
Relationship of insulin dynamics to body composition and resting energy expenditure following weight loss
Bridget M. Hron et al. · Obesity · 2015
DOI 10.1002/oby.21213
More from this paper
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →