Mixed
In Mexican adults, general adiposity (BMI or height-adjusted weight) is a stronger independent predictor of blood pressure than central adiposity (waist circumference, waist-hip ratio, or waist-height ratio), with no evidence of threshold effects.
For Mexican adults, maintaining a healthy overall body weight is more critical for controlling blood pressure than focusing solely on waist size. Since there is no 'safe' threshold for adiposity, lower general body weight is consistently associated with lower blood pressure, regardless of where the fat is stored.
In Mexican adults, often overweight or obese, markers of general adiposity were stronger predictors of blood pressure than measured markers of central adiposity, with no threshold effects.
Why this rating
Large sample size (111,911 participants) and rigorous adjustment for confounders, but cross-sectional design limits causal inference compared to RCTs.
Source
Adiposity and Blood Pressure in 110 000 Mexican Adults
Louisa Gnatiuc et al. · Hypertension · 2017
DOI 10.1161/hypertensionaha.116.08791
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