Hormonal
Tirzepatide treatment (5-15 mg once weekly) significantly improves health-related quality of life (HRQoL), including physical function and psychosocial well-being, compared to placebo in adults with obesity or overweight.
If you have obesity or overweight, treatment with tirzepatide (5-15 mg once weekly) along with lifestyle changes significantly improves your quality of life, physical function, and mental well-being compared to placebo. The greater the weight loss achieved (especially ≥5%), the greater the improvement in how you feel and function daily.
All tirzepatide groups demonstrated significant improvements in PRO scores versus placebo. There was a consistent trend of incremental PRO improvement with greater degrees of weight reduction, starting from ≥5% weight reduction.
Why this rating
Based on a large, phase 3, multicentre, randomised, placebo-controlled, double-blinded study (SURMOUNT-1).
Source
Association between weight reduction achieved with tirzepatide and quality of life in adults with obesity: Results from the <scp>SURMOUNT</scp> ‐1 study
Kimberly A. Gudzune et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.16046
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