Research
Energy balance
Greater degrees of weight reduction achieved with tirzepatide are associated with greater improvements in health-related quality of life (HRQoL), particularly when weight loss is ≥5%.
With tirzepatide, you don't need to lose a massive amount of weight to see benefits. Losing 5% or more of your body weight is associated with noticeable improvements in how you feel and function, with greater losses leading to even better outcomes.
GoodConditionalHIGH confidence
There was a consistent trend of incremental PRO improvement with greater degrees of weight reduction, starting from ≥5% weight reduction. Participants achieving ≥20% weight reduction demonstrated the greatest changes from baseline to week 72.
Why this rating
Based on subgroup analysis of a large RCT.
Source
Association between weight reduction achieved with tirzepatide and quality of life in adults with obesity: Results from the <scp>SURMOUNT</scp> ‐1 study
Kimberly A. Gudzune et al. · Diabetes Obesity and Metabolism · 2024
DOI 10.1111/dom.16046
rctCited 38×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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