Research
Adherence
There is a significant disparity in medication initiation rates between diabetes and obesity indications, with 72.2% of diabetes prescriptions filled within 60 days compared to only 46.8% of obesity prescriptions.
If you are prescribed a GLP-1 for weight loss, be aware that you are less likely to fill the prescription than someone prescribed for diabetes. This is due to insurance coverage gaps, not a lack of desire to treat. Check your coverage status before the prescription is written to avoid delays.
GoodSupportsHIGH confidence
70.2% of first-time ADM prescriptions overall and 72.2% in June 2025 had a fill within 60 days. By comparison, 46.5% of first-time AOM prescriptions overall and 46.8% in June 2025 had a fill within 60 days.
Why this rating
Large sample size, real-world data, preprint status.
Source
Monitoring Report: GLP-1 RA Prescribing Trends – March 2026 Data
Samuel Gratzl et al. · medRxiv · 2025
DOI 10.1101/2025.03.06.25323524
preprint · n=2454615Cited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- GLP-1 receptor agonists (GLP-1 RAs) are primarily prescribed as anti-diabetic medications (ADMs) rather than anti-obesity medications (AOMs), with 71.8% of first-time prescriptions designated for diabetes management and only 28.2% for obesity.Good
- Tirzepatide has surpassed semaglutide as the most commonly prescribed first-time GLP-1 RA medication in the US as of September 2025.Good
Related findings · Adherence
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- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →