Research
Mixed
Tirzepatide has surpassed semaglutide as the most commonly prescribed first-time GLP-1 RA medication in the US as of September 2025.
Tirzepatide is now the most frequently prescribed first-time GLP-1 medication in the US, overtaking semaglutide. This reflects changing prescribing preferences among physicians.
GoodSupportsHIGH confidence
Among first-time prescriptions for which use could be established... semaglutide was the most common first-time medication (n = 1,298,442), however in September 2025 tirzepatide is the most commonly prescribed first-time medication.
Why this rating
Large sample size, real-world data.
Source
Monitoring Report: GLP-1 RA Prescribing Trends – March 2026 Data
Samuel Gratzl et al. · medRxiv · 2025
DOI 10.1101/2025.03.06.25323524
preprint · n=2454615Cited 9×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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