Adherence
Adherence to sulfonylurea (SU) therapy is associated with greater weight gain in patients with type 2 diabetes compared to poor adherence.
If you are prescribed a sulfonylurea for type 2 diabetes, be aware that taking it consistently may lead to weight gain. If weight management is a priority, discuss alternative medications with your healthcare provider that have a weight-neutral or weight-loss effect.
Adherent SU patients gained 1.11 kg more than poorly adherent patients (all P < 0.01).
Why this rating
Large real-world observational study (n=2,713 SU) with regression adjustment.
Source
Real-world weight change among patients treated with glucagon-like peptide-1 receptor agonist, dipeptidyl peptidase-4 inhibitor and sulfonylureas for type 2 diabetes and the influence of medication adherence
Ginger Smith Carls et al. · Obesity Science & Practice · 2017
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