Adherence
Intensive lifestyle intervention in type 2 diabetes leads to significant weight loss and improved glycaemic control, but does not reduce cardiovascular morbidity or mortality over 10 years.
Intensive lifestyle changes help you lose weight and lower blood sugar, but they do not guarantee protection against heart attacks or death in type 2 diabetes. You may need additional medications, especially those that protect the heart and help with weight, to fully manage your cardiovascular risk.
Despite sustained positive effects associated with intensive lifestyle intervention including the need for fewer glucose-lowering drugs and increased likelihood of achieving HbA1c levels <7% (53 mmol/mol) [27], the 10-year follow-up study showed no significant difference between groups for cardiovascular morbidity and mortality [28].
Why this rating
Based on the Look AHEAD study, a major randomized controlled trial with 10-year follow-up.
Source
Management of type 2 diabetes: <scp>t</scp> he current situation and key opportunities to improve care in the <scp>UK</scp>
Steve Baín et al. · Diabetes Obesity and Metabolism · 2016
DOI 10.1111/dom.12760
More from this paper
- Intensive glucose control using sulphonylurea-insulin therapy in type 2 diabetes reduces long-term cardiovascular events and mortality, with a legacy effect persisting after the active intervention ends.Good
- SGLT2 inhibitors and GLP-1 receptor agonists offer weight loss and glycaemic control, with SGLT2 inhibitors providing cardiovascular protection beyond glucose lowering and GLP-1 agonists showing early evidence of CVD event reduction.Moderate
Related findings · Adherence
- Regular physical activity (at least 150 minutes/week of moderate-intensity) reduces all-cause and cardiovascular mortality by 20-30% and lowers the risk of type 2 diabetes by 25-35%.Strong
- Increasing physical activity from a sedentary lifestyle to an active one in middle adulthood significantly reduces the risk of coronary events compared to remaining sedentary.Strong
- Resistance exercise is the only intervention capable of consistently restoring muscle function and strength in sarcopenia, partially overcoming age-related anabolic resistance.Strong
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