Research
Mixed
Long-term weight loss maintenance is not significantly predicted by dietary adherence or caloric restriction, but is associated with baseline proteomic and gut microbiome signatures.
If you struggle to maintain weight loss despite good adherence, your baseline biology (proteins and gut bacteria) may be a factor. This suggests that personalized dietary strategies based on biological markers might be more effective than generic advice for long-term maintenance.
GoodRefutesHIGH confidence
Interestingly, long-term weight loss is less influenced by dietary intake, but more associated with individuals’ molecular features, including host factors... and microbiome composition in the gut.
Why this rating
Secondary analysis of a large RCT with multi-omics data; microbiome data from a subset (n=49).
Source
Distinct factors associated with short-term and long-term weight loss induced by low-fat or low-carbohydrate diet intervention
Xiao Li et al. · Cell Reports Medicine · 2022
DOI 10.1016/j.xcrm.2022.100870
rct · n=609Cited 23×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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