Adherence

A 12-month multi-component exercise program combined with daily multi-nutrient supplementation (whey protein, calcium, vitamin D) has limited effect on ameliorating adverse musculoskeletal consequences (bone density, muscle mass, physical function) in men with prostate cancer undergoing androgen deprivation therapy, primarily due to modest intervention adherence.

For men on prostate cancer hormone therapy, combining exercise and supplements is challenging to maintain long-term. While leg strength can improve, bone density loss often continues. Prioritize sustainable adherence over complex protocols; if you can't do 3 gym sessions and take daily supplements, focus on what you can consistently do, as the study showed low adherence led to negligible bone benefits.