Research

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In individuals with overweight or obesity at high risk of type 2 diabetes, a trajectory of weight loss followed by weight regain results in a net loss of fat-free mass (FFM) despite fat mass (FM) returning to baseline levels.

If you are overweight or obese and have experienced a cycle of losing weight and then gaining it back, be aware that your body composition may have worsened even if your weight is back to where it started. Specifically, you may have lost muscle mass (fat-free mass) while regaining fat. To counteract this, prioritize resistance training and adequate protein intake during any future weight loss attempts to preserve muscle, as simply returning to your starting weight does not restore your previous body composition.

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These individuals regained FM to baseline levels, but lost 1.50 (0.66, 2.35) kg FFM, adjusted for confounders.
Thomas Yates et al. · Diabetes Obesity and Metabolism · 2023

Why this rating

Prospective cohort study with objective BIA measurements and adjustment for multiple confounders, though observational design limits causal inference.

Source

Impact of weight loss and weight gain trajectories on body composition in a population at high risk of type 2 diabetes: A prospective cohort analysis

Thomas Yates et al. · Diabetes Obesity and Metabolism · 2023

DOI 10.1111/dom.15400

cohort · n=622Cited 22×
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DOI resolved against Crossref · corpus check 2026-06-10

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