Research
Hormonal
Consistent use of metformin (≥50% of assessments) is independently associated with slower progression of the frailty index in adults with type 2 diabetes, after adjusting for HbA1c and weight loss.
Taking metformin consistently is linked to slower physical decline in people with type 2 diabetes, even after accounting for weight loss and blood sugar levels. Discuss with your doctor if metformin is the right long-term strategy for you.
GoodSupportsHIGH confidence
After adjustment for HbA1c, use of metformin and weight loss >5% were independently associated with slower increases in frailty.
Why this rating
Large RCT data with robust statistical adjustment.
Source
An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial
Felicia Simpson et al. · Diabetes Care · 2022
DOI 10.2337/dc22-1728
rct · n=4169Cited 21×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Maintaining lower HbA1c levels (<7%) is associated with slower progression of biological aging, as measured by the deficit accumulation frailty index, over an 8-year period in adults with type 2 diabetes.Good
- Achieving a weight loss of greater than 5% is independently associated with slower progression of the frailty index in adults with type 2 diabetes, regardless of HbA1c levels.Good
Related findings · Hormonal
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