Energy balance
Achieving a weight loss of greater than 5% is independently associated with slower progression of the frailty index in adults with type 2 diabetes, regardless of HbA1c levels.
Losing more than 5% of your body weight is linked to slower physical decline in people with type 2 diabetes. This benefit holds true even if your blood sugar levels don't change drastically. Focus on sustainable weight loss through diet and exercise.
After adjustment for HbA1c, use of metformin and weight loss >5% were independently associated with slower increases in frailty.
Why this rating
Large RCT data with robust statistical adjustment for confounders.
Source
An Examination of Whether Diabetes Control and Treatments Are Associated With Change in Frailty Index Across 8 Years: An Ancillary Exploratory Study From the Action for Health in Diabetes (Look AHEAD) Trial
Felicia Simpson et al. · Diabetes Care · 2022
DOI 10.2337/dc22-1728
More from this paper
- Maintaining lower HbA1c levels (<7%) is associated with slower progression of biological aging, as measured by the deficit accumulation frailty index, over an 8-year period in adults with type 2 diabetes.Good
- Consistent use of metformin (≥50% of assessments) is independently associated with slower progression of the frailty index in adults with type 2 diabetes, after adjusting for HbA1c and weight loss.Good
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