Mixed
Switching from continuous full-dose GLP-1/IM therapy to a lower-cost, less effective alternative weight-maintenance program after reaching a weight-loss plateau generates substantial lifetime healthcare savings with only minimal reductions in quality-adjusted life years (QALYs).
If you have successfully lost weight using GLP-1 medications (like Wegovy or Ozempic) and your weight has stabilized, discuss with your doctor whether switching to a lower-cost maintenance strategy (such as a lower dose, a different medication, or a focus on lifestyle/nutrition support) is appropriate for you. This approach may save you significant money and reduce side effects while maintaining a substantial portion of your health benefits, with the option to return to full-dose therapy if you regain weight.
Our model suggested that, compared with continuous long-term full-dose GLP-1 receptor agonists or incretin mimetic drugs, the alternative weight-maintenance program would generate slightly fewer clinical benefits while generating substantial savings in lifetime health care spending.
Why this rating
Based on a validated microsimulation model (DOC-M) using trial data, but relies on assumptions about the effectiveness of the 'alternative program' which is not a single standardized intervention.
Source
Balancing innovation and affordability in anti-obesity medications: the role of an alternative weight-maintenance program
David D. Kim et al. · Health Affairs Scholar · 2024
DOI 10.1093/haschl/qxae055
Related findings · Mixed
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