Research
Hormonal
Skeletal muscle releases myokines (such as Irisin and Myostatin) during exercise, which mediate interorgan crosstalk to improve metabolic health, regulate adipose tissue, and protect against cardiovascular disease.
Understand that exercise is a systemic therapy. When you move, your muscles release signals that improve the health of your heart, brain, and fat tissue, not just the muscles themselves.
ModerateSupportsMEDIUM confidence
These myokines and other exercise-induced signaling molecules hold promise as therapeutic targets for aging and obesity-related conditions... exercise-induced secreted molecules can be produced by various tissues... facilitate communication between different tissues and organs... enhance overall metabolic health.
Why this rating
The paper is a review of mechanisms, citing various studies but noting conflicting data for some myokines (e.g., Irisin and CVD).
Source
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Julia A. Pinette et al. · Circulation Research · 2025
DOI 10.1161/circresaha.124.325614
narrative_reviewCited 20×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Regular physical exercise prevents age-related skeletal muscle dysfunction, including loss of strength and mitochondrial capacity, by inducing structural remodeling and metabolic adaptations.Good
- Myostatin acts as a negative regulator of muscle hypertrophy and cardiac pathological hypertrophy, and its inhibition or reduction through exercise can promote muscle growth and protect against certain cardiac dysfunctions.Moderate
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