Mixed
Regular physical exercise prevents age-related skeletal muscle dysfunction, including loss of strength and mitochondrial capacity, by inducing structural remodeling and metabolic adaptations.
Start or maintain regular physical activity, combining aerobic and resistance exercises, to protect your muscles from age-related decline. This is one of the most effective ways to maintain strength, mitochondrial health, and metabolic function as you age.
Exercise protects the skeletal muscle from age-associated dysfunction, including decreases in strength and mitochondrial capacity, increased fat infiltration and insulin resistance... maintaining or beginning physical activity is a well-established way to prevent or improve the effects of aging on skeletal muscle.
Why this rating
The paper cites multiple systematic reviews, meta-analyses, and large cohort studies (e.g., 880,000 participants) supporting the general efficacy of exercise.
Source
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Julia A. Pinette et al. · Circulation Research · 2025
DOI 10.1161/circresaha.124.325614
More from this paper
- Skeletal muscle releases myokines (such as Irisin and Myostatin) during exercise, which mediate interorgan crosstalk to improve metabolic health, regulate adipose tissue, and protect against cardiovascular disease.Moderate
- Myostatin acts as a negative regulator of muscle hypertrophy and cardiac pathological hypertrophy, and its inhibition or reduction through exercise can promote muscle growth and protect against certain cardiac dysfunctions.Moderate
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