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Peptide YY (PYY) analogs show greater weight loss efficacy in mice housed at thermoneutrality (30°C) compared to standard room temperature (22°C), contrary to the trend seen with GDF15.
For PYY-based therapies, preclinical data from thermoneutral mice may better reflect potential efficacy than data from cold-stressed mice, where the drug appears largely ineffective.
GoodQualifiesHIGH confidence
Peptide YY elicited greater vehicle-subtracted weight loss at 30°C (7.2% vs. 1.4%)
Why this rating
Clear statistical difference reported.
Source
Housing mice near vs. below thermoneutrality affects drug-induced weight loss but does not improve prediction of efficacy in humans
Julie Jacobsen et al. · Cell Reports · 2024
DOI 10.1016/j.celrep.2024.114501
mechanism_only · n=160Cited 19×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Housing mice at thermoneutrality (30°C) rather than standard room temperature (22°C) does not improve the prediction of human drug efficacy for weight loss, as the direction and magnitude of drug effects vary by mechanism regardless of temperature.Good
- GLP-1 receptor agonists (like semaglutide) and hFGF21 analogs produce similar weight loss efficacy in mice regardless of whether they are housed at standard room temperature (22°C) or thermoneutrality (30°C).Good
- GDF15 analogs are significantly more effective at inducing weight loss in mice housed at standard room temperature (22°C) compared to thermoneutrality (30°C), with efficacy dropping by half at higher temperatures.Good
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