Energy balance
Maintaining a weight loss of ≥7% of initial body weight for a sustained proportion of time (Time in Target Range, TTR) is associated with a significantly lower risk of composite kidney outcomes in patients with overweight/obesity and type 2 diabetes.
For individuals with type 2 diabetes and overweight/obesity, the goal should not just be to lose weight, but to keep it off. Aim to maintain a 7% reduction from your starting weight. Even if you fluctuate, spending more time within this target range significantly lowers your risk of kidney disease. This involves a combination of eating fewer calories and moving more, supported by regular counseling or self-monitoring.
A higher body weight TTR, with a weight loss target of losing ≥7% of initial weight, was associated with a lower risk of kidney outcomes in participants with overweight/obesity and T2DM.
Why this rating
Post hoc analysis of a large, randomized controlled trial (Look AHEAD) with long follow-up (median 8.0 years) and rigorous statistical adjustments, though not the primary endpoint of the parent study.
Source
Association of Body Weight Time in Target Range With the Risk of Kidney Outcomes in Patients With Overweight/Obesity and Type 2 Diabetes Mellitus
Cheng Zu et al. · Diabetes Care · 2023
DOI 10.2337/dc23-1727
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