Mixed
In adults with screen-detected type 2 diabetes, weight gain (>2%) or significant weight loss (≥5% or ≥10%) in the first five years following diagnosis is associated with a significantly higher hazard of all-cause mortality compared to maintaining stable weight, with large weight loss being particularly harmful for non-obese individuals (BMI <30 kg/m²).
If you have type 2 diabetes, especially if you are not obese, avoid significant weight loss or gain. The study suggests that maintaining your current weight is associated with lower mortality risk compared to losing or gaining weight. If you are losing weight, consult your doctor to rule out underlying health issues rather than assuming it is a positive health improvement.
Gaining >2% weight in the year after diabetes diagnosis was associated with higher hazard of all-cause mortality vs maintaining weight [Hazard Ratio(HR)(95%CI): 3.18(1.30-7.82)]. Losing ≥5% weight 1 year after diagnosis was also associated with mortality... Losing ≥10% weight over 5 years was associated with mortality among those with BMI<30kg/m2 [4.62(1.87-11.42)].
Why this rating
Observational study with wide confidence intervals and potential for confounding by indication (unintentional weight loss), though large sample size and long follow-up mitigate some risks.
Source
Association of weight loss and weight loss maintenance following diabetes diagnosis by screening and incidence of cardiovascular disease and all‐cause mortality: An observational analysis of the ADDITION‐Europe trial
Jean Strelitz et al. · Diabetes Obesity and Metabolism · 2020
DOI 10.1111/dom.14278
Related findings · Mixed
- Bariatric surgery (VSG and RYGB) is the most effective and sustainable treatment for obesity, producing marked and sustained weight loss that non-surgical interventions cannot match.Strong
- Severely protein-deficient diets (2–3% energy) induce lean body mass loss and metabolic imbalance, whereas adequate protein intake (0.66 g/kg/d minimum) is a prerequisite for maintaining muscle, bone, and physiological function.Strong
- For patients with Class III obesity (BMI >39.9 kg/m2), metabolic bariatric surgery (MBS) is significantly more effective than any currently approved medication, with BilioPancreatic Diversion (BPD) showing the highest estimated weight loss.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →