Research

Mixed

Dietary restriction (DR), including caloric restriction (CR) and intermittent fasting (IF), delays aging and extends healthspan by regulating nutrient-sensing pathways and gut microbiota.

To leverage dietary restriction for anti-aging, you don't necessarily need to cut calories drastically all day. Consider Time-Restricted Eating (eating within a 4-12 hour window) or Intermittent Fasting patterns like the 5:2 diet. These methods regulate nutrient-sensing pathways and gut microbiota similarly to strict calorie counting but are easier to sustain long-term. Focus on consistency and moderate restriction (10-30% if doing CR) to avoid negative side effects like muscle loss.

ModerateSupportsMEDIUM confidence
Dietary restriction (DR), including caloric restriction (CR), intermittent fasting (IF), and restriction of specific food compositions, can delay aging, and the main mechanisms include regulation of nutrient-sensing pathways and gut microbiota.
Hui Duan et al. · Critical Reviews in Food Science and Nutrition · 2022

Why this rating

The paper is a review summarizing multiple animal, clinical, and preclinical studies, but notes controversial effects.

Source

The road ahead of dietary restriction on anti-aging: focusing on personalized nutrition

Hui Duan et al. · Critical Reviews in Food Science and Nutrition · 2022

DOI 10.1080/10408398.2022.2110034

narrative_reviewCited 16×
Read the paper
DOI resolved against Crossref · corpus check 2026-06-10

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