Hormonal
Frequent episodic bouts of resistance exercise combined with protein ingestion result in skeletal muscle hypertrophy, primarily by driving increases in muscle protein synthesis (MPS) rather than changes in muscle protein breakdown (MPB).
To build muscle, you need to combine resistance training with protein intake. This combination works by significantly boosting muscle protein synthesis. Don't focus solely on the immediate post-workout spike; consistent training and protein consumption over time are what drive actual muscle growth.
Frequent episodic bouts of resistance exercise and protein ingestion result in skeletal muscle hypertrophy [6]. It is important to acknowledge that in many instances it is the alterations in MPS, and not MPB, that are the focus of many investigations [7–10].
Why this rating
Based on a review of multiple human studies and established metabolic principles, though specific dosing protocols are discussed as variable.
Source
Assessing the regulation of skeletal muscle plasticity in response to protein ingestion and resistance exercise
Chris McGlory et al. · Current Opinion in Clinical Nutrition & Metabolic Care · 2014
DOI 10.1097/mco.0000000000000083
More from this paper
- The D2O stable isotopic tracer methodology allows for the assessment of muscle protein synthesis (MPS) over extended periods (days to weeks) in free-living settings, overcoming the limitations of short-term infusion methods.Good
- Subcellular trafficking of signaling molecules, such as the localization of mTOR to the lysosomal membrane, is a key regulatory event in the control of muscle protein synthesis, in addition to phosphorylation.Moderate
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
This is one finding among thousands. Every one is graded and traced to its source, so you can see what the evidence actually supports. Browse the research →