Mixed
Aligning dietary macronutrient prescriptions (moderate vs. low carbohydrate) to specific genetic polymorphisms (FABP2, PPARG, ADRB3, ADRB2) does not result in greater weight loss or body composition improvements compared to non-aligned diets in sedentary women with obesity.
If you are using a genetic test to choose between a low-carb and a moderate-carb diet for weight loss, do not expect the 'aligned' diet to give you an advantage. Both diets worked similarly well (or poorly) regardless of genetic alignment. Focus on sticking to a sustainable caloric deficit and exercise routine rather than spending money on genetic diet testing.
No significant differences were observed between genotype groups (weight: A -5.00 [-3.3, -6.7], NA -4.14 [-2.2, -6.1]; fat mass: A -10.15 [-7.0, -13.6], NA -8.02 [-4.0, -12.0]...); alignment of these diets to this genetic profile did not promote greater health outcomes.
Why this rating
Randomized controlled trial with a reasonably large sample size (n=63 analyzed) and rigorous statistical controls, though limited to one demographic.
Source
Alignment of diet prescription to genotype does not promote greater weight loss success in women with obesity participating in an exercise and weight loss program
Adriana M. Coletta et al. · Obesity Science & Practice · 2018
DOI 10.1002/osp4.305
Related findings · Mixed
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