Research
Hormonal
Testosterone therapy in older men with low testosterone and symptoms improves sexual function, anemia, and bone mineral density, and prevents type 2 diabetes in high-risk men, while demonstrating cardiovascular safety in large RCTs.
If you are an older man with low testosterone and symptoms, testosterone therapy can improve sexual function, blood counts, and bone density. For those at high risk of diabetes, it significantly reduces that risk. Large recent studies confirm it is safe for the heart and prostate, so discuss this with your doctor if you meet the criteria.
WeakSupportsHIGH confidence
Recent RCTs show benefits of testosterone treatment to improve sexual function, anaemia and bone mineral density in older men, and to prevent or revert type 2 diabetes mellitus in men at high risk. Results from a large cardiovascular safety trial in men with or at risk of cardiovascular disease provide important reassurance as to cardiovascular and prostate safety of testosterone treatment.
Why this rating
Based on multiple large, high-quality RCTs (T Trials, T4DM, TRAVERSE).
Source
Testosterone Therapy in Older Men: Present and Future Considerations
Bu B. Yeap et al. · Drugs & Aging · 2025
DOI 10.1007/s40266-025-01209-1
narrative_reviewCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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