Research
Hormonal
Testosterone therapy preserves lean mass and reduces fat mass when used as an adjunct to incretin-based weight loss medications, potentially counteracting sarcopenia.
Current evidence does not yet support using testosterone to offset muscle loss from GLP-1 weight loss drugs. Resistance exercise and adequate protein intake are the recommended strategies to preserve muscle mass during weight loss.
GoodConditionalLOW confidence
Key questions remain as to whether testosterone’s anabolic and other effects can be used safely to counter reductions in lean mass associated with incretin-based weight loss medications in men with obesity
Why this rating
Based on mechanistic plausibility and observational data, but lack of RCTs.
Source
Testosterone Therapy in Older Men: Present and Future Considerations
Bu B. Yeap et al. · Drugs & Aging · 2025
DOI 10.1007/s40266-025-01209-1
narrative_reviewCited 8×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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