Hormonal
Daily urinary C-peptide excretion normalized by energy intake (CPEP/EI) serves as a valid, noninvasive physiological measure of insulin sensitivity in nondiabetic individuals, inversely correlating with the gold-standard euglycemic-hyperinsulinemic clamp.
For clinical or research settings where frequent blood draws are impractical, collecting 24-hour urine samples to measure C-peptide and dividing by total energy intake provides a reasonably accurate, noninvasive estimate of insulin sensitivity in healthy, nondiabetic adults. This method is not suitable for individuals with kidney disease.
In nondiabetic subjects, two novel estimates of IS—daily urinary C-peptide urinary excretion and glycolytic rate during an oral glucose tolerance test —were related to IS by a clamp.
Why this rating
Strong correlation (r=-0.62, P<0.01) with the gold standard in a controlled inpatient setting, but limited by renal clearance variability.
Source
Urinary C‐Peptide Excretion: A Novel Alternate Measure of Insulin Sensitivity in Physiological Conditions
José E. Galgani et al. · Obesity · 2010
DOI 10.1038/oby.2010.70
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