Research
Hormonal
The deuterated-glucose disposal test (2H-GDT), which measures glycolytic glucose metabolism via deuterated water production after an oral glucose load, correlates with insulin sensitivity measured by the clamp.
The deuterated-glucose disposal test offers a physiological measure of glycolysis that correlates with insulin sensitivity. However, its moderate correlation with the gold standard and technical complexity limit its routine clinical utility compared to simpler surrogates.
ModerateSupportsMEDIUM confidence
We confirmed that glycolytic glucose disposal rate after an oral glucose tolerance test correlates with the insulin-stimulated glucose disposal rate assessed during a clamp.
Why this rating
Correlation is moderate (r=0.60) and weaker than previous reports (r=0.95), suggesting methodological limitations or population differences.
Source
Urinary C‐Peptide Excretion: A Novel Alternate Measure of Insulin Sensitivity in Physiological Conditions
José E. Galgani et al. · Obesity · 2010
DOI 10.1038/oby.2010.70
cross_sectional · n=30Cited 14×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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