Energy balance
Adding GLP-1 receptor agonists (GLP1RAs) to metformin effectively improves anthropometric measures (weight, BMI, waist circumference, waist-to-hip ratio) in women with PCOS.
For PCOS patients struggling with weight, adding a GLP-1 receptor agonist (like semaglutide or liraglutide) to metformin is a highly effective strategy for reducing body weight and waist circumference, addressing the core metabolic driver of the syndrome.
Glucagon-like peptide-1 receptor agonists (GLP1RAs) effectively modified various anthropometric measurements, such as weight, body mass index, waist circumference, and waist-to-hip ratio.
Why this rating
Systematic review of 16 RCTs, but heterogeneity prevented meta-analysis.
Source
Comparative Effectiveness of Antidiabetic Drugs as an Additional Therapy to Metformin in Women with Polycystic Ovary Syndrome: A Systematic Review of Metabolic Approaches
Maryam Heidarpour et al. · International Journal of Endocrinology · 2024
DOI 10.1155/2024/9900213
More from this paper
- Adding DPP4 inhibitors (e.g., sitagliptin) to metformin significantly improves glycemic profiles (fasting blood sugar and HOMA-IR) in women with PCOS compared to metformin alone.Moderate
- Adding Thiazolidinediones (TZDs) to metformin has the most significant influence on lipid levels (specifically lowering LDL and improving lipid profiles) in women with PCOS.Moderate
- None of the combined antidiabetic therapies (DPP4i, GLP1RA, TZD, SGLT2i) showed a significant change in blood pressure compared to metformin alone in women with PCOS.Moderate
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