Research
Hormonal
Resmetirom (Rezdiffra), a thyroid hormone receptor-beta (THR-β) agonist, is the first FDA-approved pharmacotherapy for non-cirrhotic MASH in adults with moderate to advanced liver fibrosis (F2-F3), demonstrating significant resolution of MASH and improvement in liver fibrosis compared to placebo.
If you have non-cirrhotic MASH with moderate to advanced fibrosis, ask your doctor about Resmetirom (Rezdiffra). It is the first FDA-approved drug for this condition, taken orally alongside diet and exercise, and has been shown to significantly improve liver health compared to placebo.
StrongSupportsHIGH confidence
Namely, in March 2024, a thyroid hormone receptors β (THR-β) agonist, resmetirom (Rezdiffra™), became the first drug approved by the Food and Drug Administration (FDA) in the United States for the treatment of non-cirrhotic MASH in adults with moderate to progressed liver fibrosis in combination with diet and exercise [20].
Why this rating
Based on Phase 3 MAESTRO-NASH RCT results leading to FDA accelerated approval.
Source
MAFLD Pandemic: Updates in Pharmacotherapeutic Approach Development
Farah Khaznadar et al. · Current Issues in Molecular Biology · 2024
DOI 10.3390/cimb46070376
narrative_reviewCited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
More from this paper
- Pegozafermin (BIO89-100), an FGF-21 analog, demonstrates improvement in liver fibrosis in patients with MASH, as shown in Phase 2b trials, and has entered Phase 3 clinical trials.Good
- Semaglutide, a GLP-1 receptor agonist, significantly reduces hepatic steatosis, inflammation, and liver stiffness in patients with MAFLD, although its effect on reducing fibrosis stage remains uncertain.Good
- SGLT2 inhibitors (flozins) such as dapagliflozin and empagliflozin show promise in reducing liver steatosis and inflammation in MAFLD patients, with several Phase 3 and 4 trials ongoing.Good
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