Research
Hormonal
Pegozafermin (BIO89-100), an FGF-21 analog, demonstrates improvement in liver fibrosis in patients with MASH, as shown in Phase 2b trials, and has entered Phase 3 clinical trials.
Pegozafermin is an experimental drug for MASH that works by mimicking FGF-21. It is given as a subcutaneous injection every two weeks. It is currently in Phase 3 trials and not yet approved.
GoodSupportsHIGH confidence
Loomba et al. (2023) reported that in a phase 2b placebo-controlled RCT (NCT04929483) which enrolled a total of 222 patients, pegozafermin demonstrated fibrosis improvement in patients with MASH [48].
Why this rating
Based on Phase 2b RCT results; Phase 3 ongoing.
Source
MAFLD Pandemic: Updates in Pharmacotherapeutic Approach Development
Farah Khaznadar et al. · Current Issues in Molecular Biology · 2024
DOI 10.3390/cimb46070376
narrative_reviewCited 13×
Read the paper DOI resolved against Crossref · corpus check 2026-06-10
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- Resmetirom (Rezdiffra), a thyroid hormone receptor-beta (THR-β) agonist, is the first FDA-approved pharmacotherapy for non-cirrhotic MASH in adults with moderate to advanced liver fibrosis (F2-F3), demonstrating significant resolution of MASH and improvement in liver fibrosis compared to placebo.Strong
- Semaglutide, a GLP-1 receptor agonist, significantly reduces hepatic steatosis, inflammation, and liver stiffness in patients with MAFLD, although its effect on reducing fibrosis stage remains uncertain.Good
- SGLT2 inhibitors (flozins) such as dapagliflozin and empagliflozin show promise in reducing liver steatosis and inflammation in MAFLD patients, with several Phase 3 and 4 trials ongoing.Good
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