Mixed
Achieving optimal levels of waist circumference, glomerular filtration rate, and urine albumin-to-creatinine ratio (each weighted 2 points) and glycated hemoglobin/blood pressure (each weighted 1 point) is significantly associated with a lower risk of heart failure in type 2 diabetes.
For individuals with Type 2 Diabetes, managing heart failure risk requires a multi-faceted approach. Prioritize achieving target levels for waist circumference, kidney function (GFR and urine albumin), blood pressure, and blood sugar. The study suggests that controlling waist circumference and kidney markers may offer greater protection against heart failure than controlling blood pressure or blood sugar alone.
High baseline CMH score (6–8) was significantly associated with lower overall HF risk (adjusted hazard ratio [HR], ref = low score (0–3): 0.31, 95% confidence interval [CI] 0.21–0.47)... The CMH score included 2 points each for target levels of waist circumference, glomerular filtration rate, urine albumin-to-creatinine ratio, and 1 point each for blood pressure and glycated haemoglobin at target.
Why this rating
Large randomized trial (Look AHEAD) with long follow-up (median 12.4 years) and external validation (ACCORD), though it is a secondary analysis.
Source
Optimal cardiometabolic health and risk of heart failure in type 2 diabetes: an analysis from the Look AHEAD trial
Kershaw V. Patel et al. · European Journal of Heart Failure · 2022
DOI 10.1002/ejhf.2723
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