Macro partitioning
Iso-caloric substitution of poly-unsaturated fat for saturated fat is associated with an increased risk of cancer-related mortality.
If you are replacing saturated fats (e.g., from butter, cheese, or red meat) with poly-unsaturated fats (e.g., from vegetable oils, nuts, or fish), this study suggests your risk of dying from cancer may increase by 12%. Consider balancing your fat intake and not relying solely on PUFA-rich oils as a health strategy.
Independently of animal protein, substituting poly-unsaturated fat for saturated fat increased cancer-related mortality risk by 12 percent.
Why this rating
Prospective cohort study with robust adjustment for confounders; however, the specific mechanism for increased cancer mortality with PUFA is not fully elucidated in the text.
Source
Effect of Iso-Caloric Substitution of Animal Protein for Other Macro Nutrients on Risk of Overall, Cardiovascular and Cancer Mortality: Prospective Evaluation in EPIC-Heidelberg Cohort and Systematic Review
Rashmita Bajracharya et al. · Nutrients · 2023
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