Hormonal
Subcutaneous semaglutide 2.4 mg administered once weekly, combined with lifestyle interventions, produces sustained, clinically significant weight loss (average 14.9% reduction from baseline) in adults with obesity or overweight.
If you have obesity or are overweight, a once-weekly injection of semaglutide (2.4 mg) combined with lifestyle changes can lead to significant, sustained weight loss, averaging nearly 15% of your body weight. While you may experience mild, temporary nausea, the weekly schedule is designed to improve adherence compared to daily treatments. This option is particularly relevant if other GLP-1 agonists like liraglutide have not provided sufficient results.
Results showed that among obese or overweight participants, semaglutide 2.4 mg once a week plus lifestyle interventions correlated with sustained, clinically significant weight loss... In all randomized patients, the semaglutide 2.4 mg treatment group lost 14.9% from the average baseline weight of 105.3 kg, whereas the placebo group lost 2.4%.
Why this rating
Based on a large, double-blind, randomized controlled trial (Wilding et al., N=1961) cited as a key piece of evidence.
Source
New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation
Yalin Liu et al. · Frontiers of Medicine · 2022
DOI 10.1007/s11684-021-0873-2
Related findings · Hormonal
- Initial treatment for type 2 diabetes should be a combination of metformin and either an SGLT-2 inhibitor or a GLP-1 receptor agonist to achieve cardiorenal protection, rather than monotherapy or older agents like sulfonylureas.Strong
- For patients with specific monogenic obesity syndromes (leptin deficiency, POMC/PCSK1/LEPR mutations), targeted pharmacotherapy (recombinant leptin or setmelanotide) is highly effective and should be prioritized, unlike in polygenic obesity.Strong
- Continued weekly administration of 2.4 mg subcutaneous semaglutide prevents weight regain and promotes further weight loss in adults with overweight or obesity, whereas switching to placebo results in significant weight regain.Strong
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